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It should be noted that the absolute values should be considered in relation to the cellular concentration of the GST, such that the approximately 3- to 4-fold lower specific activities of SscGST A2-2, CjaGST A3-3, and HsaGST A1-1, if required, could be compensated for by a higher expression level of the protein

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The extract of chestnut leaf works by suppressing the Nrf2-mediated antioxidant system and may increase ROS production and thereby promote paclitaxel-induced apoptotic cell death