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The percentage of patients receiving GLP-1 medications both before and after bariatric surgery also showed steady growth, rising from 0.5% in 2018 to 3.3% in 2023, calling into question the extent to which GLP-1s are a replacement versus a supplemental therapy

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Use of opioids for an extended period of time may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility

Lipid-lowering effect of berberine in human subjects and rats