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Animal models struggle to accurately replicate the pathogenesis of patients, a fundamental issue that hinders the development of laboratory drugs

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[12] Published and anecdotal evidence further indicates that recreational consumption of kava beverages can often exceed these levels, surpassing the kavalactone doses used in clinical settings for the treatment of anxiety, which are aqueous extracts containing 140250 mg, taken once per day over six weeks, have demonstrated no significant toxicity

Damage to the motor neurons, which are linked to movement, can lead to weakened muscles, making it difficult to get around

B12 overdoses are unusual