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Prior to the advent of GLP-1s, diet and exercise or bariatric surgeries were the main routes to weight loss for obese Americans

A detailed clinical evaluation is conducted to review medical history, previous illnesses or procedures, current symptoms, medications, and existing health conditions

Combine with regular exercise and modest dietary consistency

The pain of pancreatitis is typically more severe and persistent than common gastrointestinal side effects associated with GLP-1 receptor agonists, such as mild nausea or dyspepsia, which tend to be transient and improve over time

Best case: EVOKE produces a stronger absolute gap and higher percent slowing on CDRSB, along with acceptable discontinuation rates