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PE-22-28 also activates serotonergic neurons in the dorsal raphe nucleus, the brain region that serves as the primary source of serotonin projections throughout the central nervous system

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Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N (2013) Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism