10.1056/NEJMoa2032183 [DOI] [PubMed] [Google Scholar] Williams, D
Both approaches have evidence behind them, although daily dosing has been studied more extensively
In evidence in published studies and clinical experience, it is mentioned that most people discontinued GLP-1 treatment due to the side effects
7 How GLP-1 drugs may reshape addiction pathways GLP-1 RAs interact with the mammalian mesolimbic reward system and have been proposed to modulate dopaminergic signaling in circuits involving the ventral tegmental area, nucleus accumbens, and other reward-related regions, thereby reducing the reinforcing value of food and some substances in preclinical models
While enteral administration offers several advantages over other routes of drug delivery in terms of convenience, promoting medication compliance, it faces several obstacles, of which the most widely recognized are inefficient absorption owing to physical barriers and an acidic microenvironment, along with degradation by proteases and the first-pass metabolism in the liver
