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PMID: 33557137

The lower doses may provide anti-inflammatory benefits without the aggressive appetite suppression of full therapeutic doses

Kathryn Horton, a board-certified internal medicine physician, stated it directly: "Tirzepatide is a synthetic peptide that is rapidly degraded by digestive enzymes within the gastrointestinal tract." The larger molecular size and chemical modifications that enable dual-receptor agonism "currently pose significant challenges for the development of an effective oral formulation." For sublingual delivery specifically, the absorption story is slightly different but still problematic

EVIDENCE SUMMARY Motivational interviewing involves assessing a patient's motives for change and acting as a supportive partner to empower them in the process ( Table 2 )

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