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Biotin injections are generally well-tolerated, but some people may experience mild side effects, such as temporary redness or soreness at the injection site

Amrouche-Mekkioui I, Djerdjouri B

For confirmed deficiency with neurological symptoms , intramuscular cyanocobalamin injections are preferred, typically administered as 1000 mcg daily for one week, then weekly for four weeks, followed by monthly maintenance therapy

Following the intervention, 14 (23.3%) had a normal condition, 13 (21.7%) mild, 19 (31.7%) moderate, and 11 (18.3%) had severe depression scale at the 3 rd week of treatment