I did the calculation and it should be 5xx instead of 8xx calories
Front Neurosci 9:111 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue
While the detectable glutarylation following ML226 treatment suggested that ABHD11 may be involved in regulating this modification, the glutaryl antibody was raised against glutaryl-lysine, making it unlikely that it could reliably detect lipoyl-glutarylation species
Although only limited support was found for the possibility that LOH is a strongly selected driver of loss of such mutations, LOH could also be detrimental if it reduced critical gene products
For practical reference, Tonum's Motus provides a clear example of an oral, trial backed product that is carefully dosed and transparent about clinical results