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However, these are only surrogate outcomes the trial did not establish a clear reduction in major adverse cardiovascular events

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These factors contributed strongly to development of the most commercially successful GLP-1 RA product, Victoza, earning last year ~$3.4 billion and controlling over 50% of the overall GLP-1 RA market

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The importance of the dendritic pool of mitochondria has been confirmed by the fact that in hippocampal neurons, the depletion of mitochondria in dendrites diminishes the number of synapses and spines [31]